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Favipiravir(Fabiflu)

Favipiravir(Fabiflu) is an anti viral medication used to treat influenza in japan.. It is a pyrazine carboxamide derivative.. Glanmerk pharmaceutical claim that,the drug has been used to treat mild to moderate symptoms of coronavirus.. It has a broad spectrum of activity and protection against RNA virus and in clinical trials, it has shown effectiveness across age of 20 to 90 years of patient.. Mode of action It target RNA polymerase ,the enzyme that helps the multiplication of the viral RNA in the body.. Adverse effect 1-Dizziness 2-Diarhhea 3-Abdominal Pain 4-Rashes 5-throat pain Dose 200 mg tablet

Amphotericin B

It is obtained from strptomyces Nodous. It is Amphoteric in nature Mechanism of action Amphotericin B binds to ergosterol in fungal cell membrane ,forms pores in cell membrane ,cell content leak out and cell death Antifungal spectrum Aspergillus Blastmyces dermatitidis Candida albicans Cryptococcus neoformans Resistance Replacement of ergosterol by other sterols in fungal plasma membrane.. Pharmacokinetic Poorly absorbed orally Insoluble in water ,so colloidal suspension prepared with sodium deoxycholate Protein bounding - 90% bound to plasma products (proteins) Metabolised in liver slowly excreted in urine.. Administration and Dose Systemic mycosis : Iv route 50mg vial- Suspended in 10ml H20 and the dil with 500 ml glucose.. 0.5mg/kg to 1mg/kg Vaginitis :Topical Otomycosis :3% drops Adverse effects Fever Headache Nausea Vomiting Can be treated with hydrocortisone o.6mg/kg.. Uses Nephrotoxicity Hypokalemia CNS Toxicity Hepatotoxicity rarely

Tetracycline

Tetracycline It is a class of antibiotics having a nucleus of four rings.. They are bitter solids and are slightly water soluble.. Tetracycline classification Short acting -Tetracycline oxytetracyclime Intermediate acting -Democlocycline Long Acting -Doxycycline, Minocycline Mechanism of action Tetracycline are specific inhibitors of bacterial protein Synthesis.. They bind to the 30s ribosomal subunit and thereby prevent the binding of aminoacyl plus RNA to the mRNA ribosome complex.. They also inhibit protein synthesis in the host, but areless likely to reach the concentration required because eucaryoticcls don't have tetracycline upateke mechanism.. Spectrum of Activity Broad spectrum antibiotic active agianst gram positive and gram negative bacteria, spirochetes mycoplasma.. Pharmacokinetic Orally absorbed The capsule shoud be taken 1 or 2 hour before food.. 60-70% absorbed Adverse drug effects Nausea Sore throats Headache Photo

Zidovudine

Zidovudine It is the first antiviral drug used in HIV.. It is the thymidine analogue.. Mechanism of action Inhibiting the enzyme reverse transcriptase, that HIV uses to make DNA and therefore decreases replication of the virus.. Pharmcokinetic Route -By mouth, Iv rectal Suppository Complete absorption PB (30 to 38%) Metablosied in liver Adverse affect Headache Nausea vomiting Anorexia Insmonia Hepatitis Myosites Bone marrow toxicity Uses Mainly used for the treatment if HlV Decreases rate of progression and prolong survival.. Prevents mother to newborn transmission of HlV..

Drug interaction

Drug interaction is refers to a modification of response by another drug when they are administerd simutaniously or in quick session ..The response is either increased or decreased in intensity, sometimes abnormal different type of response is recorded .. Higher chances of drug interaction seen when a person is taking more than one drug at same time for different problems .. Drug given in combinations also, and they worked very well but those drugs have been selected and has complement with each other .. More commonly multiple drugs are used to treat patient who is suffering from two or more diseases ..like hypertension and disbeties .. The chance of unintented effect are greater.. The severity in most cases is highly unpredictable.. However, the doctor must know which drug are not prescribe cocurrently.. Ex-Anti hypertensive, Diabetes, Anti anginal, Anti asthmatic.. The physician may prescribed certain drug for an incurrent illness, which may interact with those already been

Virus

Virus are not proper lying organism but consist of genome (DNA or RNA).. They are smaller in size with simple chemical composition .. These are stored in capsule made up of protein and covered with lipid layer The viruses only replicate within the host cell and the viral replication depends on the metabolic process of the individual cell.. Viruses doesn't pass the cell wall but they RNA or DNA enclosed in a cell of protein called Capsid.. From the past 50 years,virus are detected have been identified in the infected cell and some viruses have their own which may have higher affinity for some antimetabolites.. Various drugs have been developed which targeted ,virus specific steps like cell penetration, uncoating reverse transcription etc.. Drugs are different for differ kind of viruses.. Drugs for non reterovial 1-Anti-herpes virus - Idoxuridine, Acyclovir 2-Anti-hepatitis drug For hepatitis B -Lamavudine, Tenofour For hepatitis C -Ribovirin 3-Anti influenza

Eye problems

This problem is very normal From last few months, Due to covid-19 'All school colleges were closed last 4 months Students taking online classes, mostly people do work from home beacuse of the excess use of phones laptops,Eye gets the high pressure, and it may cause glaucoma... Glau coma is a eye problem,where the nerve connecting, the eye to the brain is damaged, mainly due to high pressure on eye.. Symptoms include like blurred vision ,Eye pain with nausea ,vision loss.. Eye protection 1-Always use your phone with some distance 2-Eat green vegetables ND healthy food 3-Take vitamin B and B12(dietry source) 4-Exercise daily 5- Use eye drops prescribed by doctor 6-Taking supplements of folic acids 7- Reduce pressure on eyes .. Treatment of glaucoma Eye drop Laser surgery Medication(Beta blockers)

MIGRAINE

Migraine is a mental disorder characterized by severe headache usually restricted to one side of your head.. Nowadays migraine seems to be normal problem of people's.. But if you are not taking this seriously this problem become dengerous and maybe life threatening .. Symptoms include like nausea, vomiting sensitivity to light, flash right, loose Motions ,reduce hunger.. The main cause of migraine is continous headache, over thinking .. There are mainly two types of migraine 1-Migraine (Classical migraine) -Headache is processed by visual or other neurological symptoms .. 2-Migraine (common migraine) -immediate pain cause because of dilation of cranial blood vessels.. Drug therapy for migraine has to be individualized ,severity and frequency of attack and response of individual patient to drug used to determine the choice.. Mild migraine - Once attack in Month tolerable attack ... Simple analgesic - paracetamol , aspirin NSAIDS - ib

Chloroquine

Chloroquine is an anti malarial drug.. It is also known as chloroquine phosphate Recently"Doctors found that Hydroxy chloroquine is used in the treatment of coronavirus ,and it shows good result in the recover of covid patients.. Hydroxy chloroquine reduce fever and fever is the main symptom of corona virus.. India supply chloroquine to many countries including Italy, America.. Chloroquine is an antimalarial drug that used to treat high fever caused by the mosquito bite .. Hydroxy chloroquine is the metabolite of chloroquine , it is less toxic used to treat rheumatoid arthritis.. Mode of action There is no well known action of chloroquine ' chloroquine used to inhibit the formation of hemozoin (HZ) from the released heam by the digestion of hemoglobin in there acidic vocule .. The free heam then lysis membrane and leads to parasite death.. USES 1-Hepatic amoebiasis 2-Giardiasis 3-Clonorchis sinesis 4-Rheumatoid arthritis 5-Malaria Side effects 1

Plasma (Covid -19)

Plasma is the 'yellowish liquid 'component of the blood that carries cells and proteins throught the body..It holds the blood cells of whole blood in suspension.. It makes up about half of the body's total blood volume It takes (55%) of blood volume.. In which 92% is water and rest of proteins, minerals,salts.. How does plasma useful to covid -19 patient in recovery If you recover from the novel corona virus so, you are able to donate the plasma.. Because you are suffering from coronavirus(Covid -19) and you totally recover ,your blood plasma contains antibodies, these antibodies help the other patient to fight against corona virus and the patient recover soon .. This treatment is still working and people gets good results.. Delhi open it's first plasma bank in India You have chance to save other person life.. There is no need to be scareed for the plasma donation.. You don't need to face any problem.. If you donate your plasma.. You