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HYPERTENSION (HIGH BLOOD PRESSURE)

HYPERTENSION  Hypertension is a very common disorder  particularly in past middle age..  Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility..  Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of  your blood pushing , against the wall of the artries..  The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems ..  It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension   Dizziness   Highblood pressure   Nausea   Vomiting   Irregular heartbeat   Mental confusion *What causes Hypertension . High salt in you diet  .Family history of High blood pressure  .Stress  .Lack of physical exercise  .Excess us
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Dexamethasone

Dexamethasone  Dexamethasone is a corticosteroid..   Very potent and highly selective glucocorticoid drug..  US researcher found that Dexamethasone can save patients from death due to corona virus (covid -19)..  Deaxamethasone cut the risk of death by 1/3 for those patient on ventilators and on oxygen it cut the death rate by 1/5 this study is given by' Peter hobby' student of oxford university.. Mode of action  Corticosteroids penetrate cell and binds to a high affinity cytoplasmic receptor complex that allow its migration and binding to glucocorticood response element (GRE) of specific mRNA..  It is long acting ,causes pitiutary  adrenal suppresion .. Dose   . 0.5-5mg/day (oral route)  .For edema cerbal 4-20mg/ day Uses  .It help to relieves in various parts of body  .It is used to treat swelling allergic reactions skin problems arthritis kidney..  .It is also used to treat certain type of cancers..  Adverese effect  Mineralocorticoid-  Sodium water retention, e
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Favipiravir(Fabiflu)

Favipiravir(Fabiflu)  is an anti viral medication used to treat influenza in japan..  It is a pyrazine carboxamide derivative..  Glanmerk pharmaceutical claim that,the drug has been used to treat mild to moderate symptoms of coronavirus..  It has a broad spectrum of activity and  protection against RNA virus and in clinical trials, it has shown effectiveness across age of 20 to 90 years of patient..  Mode of action   It target RNA polymerase ,the enzyme that helps the multiplication of the viral RNA in the body..  Adverse effect   1-Dizziness  2-Diarhhea  3-Abdominal Pain  4-Rashes  5-throat pain Dose   200 mg tablet 
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Amphotericin B

It is obtained from strptomyces Nodous.  It is Amphoteric in nature  Mechanism of action Amphotericin B binds to ergosterol in fungal cell membrane ,forms pores in cell membrane ,cell content leak out and cell death  Antifungal spectrum   Aspergillus  Blastmyces dermatitidis  Candida albicans Cryptococcus neoformans  Resistance   Replacement of ergosterol by other sterols in fungal plasma membrane..  Pharmacokinetic   Poorly absorbed orally  Insoluble in water ,so colloidal suspension prepared with sodium deoxycholate  Protein bounding - 90% bound to plasma products (proteins)  Metabolised in liver slowly excreted in urine..  Administration and Dose   Systemic mycosis : Iv route  50mg vial- Suspended in 10ml H20 and the dil with 500 ml glucose..  0.5mg/kg to 1mg/kg Vaginitis :Topical  Otomycosis :3% drops  Adverse effects  Fever  Headache  Nausea  Vomiting  Can be treated with hydrocortisone o.6mg/kg.. Uses Nephrotoxicity  Hypokalemia  CNS Toxicity  Hepatotoxicity rarely
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Drug interaction

Drug interaction is refers to a modification of response by another drug when they are administerd simutaniously or in quick session ..The response is either increased or decreased in intensity, sometimes abnormal different type of response is recorded .. Higher chances of drug interaction seen when a person is taking more than one drug at same time for different problems .. Drug given in combinations also, and they worked very well but those drugs have been selected and has complement  with each other .. More commonly multiple drugs are used to treat patient who is suffering from two or more diseases ..like hypertension and disbeties .. The chance of unintented effect are greater..  The severity in most cases is highly unpredictable.. However, the doctor must know which drug are not prescribe cocurrently.. Ex-Anti hypertensive, Diabetes, Anti anginal, Anti asthmatic..  The physician may prescribed certain drug for an incurrent illness, which may interact with those already been
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