Skip to main content

HYPERTENSION (HIGH BLOOD PRESSURE)

HYPERTENSION  Hypertension is a very common disorder  particularly in past middle age..  Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility..  Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of  your blood pushing , against the wall of the artries..  The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems ..  It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension   Dizziness   Highblood pressure   Nausea   Vomiting   Irregular heartbeat   Mental confusion *What causes Hypertension . High salt in you...
Post a Comment

Zidovudine

Zidovudine 
It is the first antiviral drug used in HIV.. 
It is the thymidine analogue.. 

Mechanism of action 
Inhibiting the enzyme reverse transcriptase, that HIV uses to make DNA and therefore decreases replication of the virus.. 

Pharmcokinetic 
Route -By mouth, Iv rectal 
Suppository 
Complete absorption 
PB (30 to 38%)
Metablosied in liver

Adverse affect 
Headache 
Nausea 
vomiting 
Anorexia 
Insmonia 
Hepatitis 
Myosites 
Bone marrow toxicity 

Uses 
Mainly used for the treatment if HlV Decreases rate of progression and prolong survival..
Prevents mother to newborn transmission of HlV..

Labels:

Comments

Post a Comment

Popular posts from this blog

Tetracycline

Tetracycline   It is a class of antibiotics having a nucleus of four rings..  They are bitter solids and are slightly water soluble..  Tetracycline classification   Short acting -Tetracycline oxytetracyclime  Intermediate acting -Democlocycline  Long Acting -Doxycycline, Minocycline  Mechanism of action   Tetracycline are specific inhibitors of bacterial protein Synthesis..  They bind to the 30s ribosomal subunit and thereby prevent the binding of aminoacyl plus RNA to the mRNA ribosome complex..  They also inhibit protein synthesis in the host, but areless likely to reach the concentration required because eucaryoticcls don't have tetracycline upateke mechanism..  Spectrum of Activity   Broad spectrum antibiotic active agianst gram positive and gram negative bacteria, spirochetes mycoplasma..  Pharmacokinetic   Orally absorbed The capsule shoud be taken 1 or 2 hour before food..  60-70% ab...
2 comments
Read more

Clinical trials

Clinical trials When the world is suffering from this pandemic and waiting for the vaccine, the researchers and scientist working hard to make covid-19 vaccine..  But all vaccine are in their phases of clinical trials.. After the successful completion of trials, vaccine is approved from higher authorities.. Before the clinincal trial, their is a preclinical trials In which the drug susbstance or sample,we made is tested on animals.. Only after the successful completion of preclinical trials..The drug sample is approved for clinical trials..  What is clinical trials?  The first proper clinical trial was conducted by the physician Linb.. Clinical trial is a systematic investigation in human subjects for evaluating the safety and efficacy of a new new drug substance..  There are 4 phases of clinical trials..     Phase 0   .Microdosing study    .Not been technally fully developed   . Nor mendatory    .Less than 1/...
4 comments
Read more

Chloroquine

Chloroquine is an anti malarial drug..  It is also known as chloroquine phosphate  Recently"Doctors found that Hydroxy chloroquine is  used in the treatment of coronavirus ,and it shows good result in the recover of  covid patients.. Hydroxy chloroquine reduce fever and fever is the main symptom of corona virus..  India supply chloroquine to many countries including Italy, America..  Chloroquine is an antimalarial drug that used to treat high fever caused by the mosquito bite ..  Hydroxy chloroquine is the metabolite of chloroquine , it is less toxic used to treat rheumatoid arthritis.. Mode of action  There is no well known action of chloroquine ' chloroquine used to inhibit the formation of hemozoin (HZ) from the released heam by the digestion of hemoglobin in there acidic vocule ..  The free heam then lysis membrane and leads to parasite death..  USES 1-Hepatic amoebiasis  2-Giardiasis  3-Clonorchis ...
1 comment
Read more