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HYPERTENSION (HIGH BLOOD PRESSURE)

HYPERTENSION  Hypertension is a very common disorder  particularly in past middle age..  Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility..  Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of  your blood pushing , against the wall of the artries..  The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems ..  It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension   Dizziness   Highblood pressure   Nausea   Vomiting   Irregular heartbeat   Mental confusion *What causes Hypertension . High salt in you...
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Amphotericin B

It is obtained from strptomyces Nodous. 
It is Amphoteric in nature 

Mechanism of action
Amphotericin B binds to ergosterol in fungal cell membrane ,forms pores in cell membrane ,cell content leak out and cell death 

Antifungal spectrum 
Aspergillus 
Blastmyces dermatitidis 
Candida albicans
Cryptococcus neoformans 

Resistance 
Replacement of ergosterol by other sterols in fungal plasma membrane.. 

Pharmacokinetic 
Poorly absorbed orally 
Insoluble in water ,so colloidal suspension prepared with sodium deoxycholate 
Protein bounding - 90% bound to plasma products (proteins) 
Metabolised in liver slowly excreted in urine.. 

Administration and Dose 
Systemic mycosis : Iv route 
50mg vial- Suspended in 10ml H20 and the dil with 500 ml glucose.. 
0.5mg/kg to 1mg/kg
Vaginitis :Topical 
Otomycosis :3% drops 

Adverse effects 
Fever 
Headache 
Nausea 
Vomiting 
Can be treated with hydrocortisone
o.6mg/kg..

Uses
Nephrotoxicity 
Hypokalemia 
CNS Toxicity 
Hepatotoxicity rarely 
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