HYPERTENSION Hypertension is a very common disorder particularly in past middle age.. Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility.. Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of your blood pushing , against the wall of the artries.. The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems .. It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension Dizziness Highblood pressure Nausea Vomiting Irregular heartbeat Mental confusion *What causes Hypertension . High salt in you...
It is also known as chloroquine phosphate
Recently"Doctors found that Hydroxy chloroquine is used in the treatment of coronavirus ,and it shows good result in the recover of covid patients..
Hydroxy chloroquine reduce fever and fever is the main symptom of corona virus..
India supply chloroquine to many countries including Italy, America..
Chloroquine is an antimalarial drug that used to treat high fever caused by the mosquito bite ..
Hydroxy chloroquine is the metabolite of chloroquine , it is less toxic used to treat rheumatoid arthritis..
Mode of action
There is no well known action of chloroquine ' chloroquine used to inhibit the formation of hemozoin (HZ) from the released heam by the digestion of hemoglobin in there acidic vocule ..
The free heam then lysis membrane and leads to parasite death..
USES
1-Hepatic amoebiasis
2-Giardiasis
3-Clonorchis sinesis
4-Rheumatoid arthritis
5-Malaria
Side effects
1-Nausea
2-vomiting
3-itching
4-Uneasines
5-frequent headache
Use of these drugs for long time (As need in arthritis) you may lose of vision because it damage your Retinal..
Loss of hearing, rashes, Allergy, mental disturbance may occur through long term use..
DOSE
500mg tablet
Bitter in taste
Tablet shouldn't be chewed
Injected through parental (i v) route..
And not injected through ( im) route
Pharmacokinetic
Orally administed
Well absorbed max 2-3 hrs
50%bound to plasma
Excreted in urine
Chloroquine resistance
Chloroquine resistance is due to decreased accumulation chloroquine in the food vacuole (Organelle like structure in which the breakdown of hemoglobin and the detoxification of hem occurs)
Chloroquine resistance among p. Vivax has been slow !!
BUT P. falcipuram has wide spread in India
P. Falcipuram produces more severe form of malaria with considerable mortality ..
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