HYPERTENSION Hypertension is a very common disorder particularly in past middle age.. Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility.. Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of your blood pushing , against the wall of the artries.. The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems .. It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension Dizziness Highblood pressure Nausea Vomiting Irregular heartbeat Mental confusion *What causes Hypertension . High salt in you diet .Family history of High blood pressure .Stress .Lack of physical exercise .Excess us
It is obtained from strptomyces Nodous. It is Amphoteric in nature Mechanism of action Amphotericin B binds to ergosterol in fungal cell membrane ,forms pores in cell membrane ,cell content leak out and cell death Antifungal spectrum Aspergillus Blastmyces dermatitidis Candida albicans Cryptococcus neoformans Resistance Replacement of ergosterol by other sterols in fungal plasma membrane.. Pharmacokinetic Poorly absorbed orally Insoluble in water ,so colloidal suspension prepared with sodium deoxycholate Protein bounding - 90% bound to plasma products (proteins) Metabolised in liver slowly excreted in urine.. Administration and Dose Systemic mycosis : Iv route 50mg vial- Suspended in 10ml H20 and the dil with 500 ml glucose.. 0.5mg/kg to 1mg/kg Vaginitis :Topical Otomycosis :3% drops Adverse effects Fever Headache Nausea Vomiting Can be treated with hydrocortisone o.6mg/kg.. Uses Nephrotoxicity Hypokalemia CNS Toxicity Hepatotoxicity rarely