HYPERTENSION Hypertension is a very common disorder particularly in past middle age.. Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility.. Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of your blood pushing , against the wall of the artries.. The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems .. It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension Dizziness Highblood pressure Nausea Vomiting Irregular heartbeat Mental confusion *What causes Hypertension . High salt in you diet .Family history of High blood pressure .Stress .Lack of physical exercise .Excess us
Digoxin It is the source of digitalis lonata.. Digoxin is a cardiac glycoside drug And have cardiac inotropic property.. It contain aglycone part that are attached to one or more sugar(glucose or degitoxoce) .. The aglycone part contain cyclopentanoperhydrophenanthrene Sterioid ring.. It is the only drug that are used to treat heart failure (Congestive heart failure) . . Mode of action Increases the contractality of the heart muscle, by inhibiting the activity of an enzyme (ATPase) And controls the movement of calcium, sodium, potassium into heart muscle.. Increases cardiac output with a subsquent decreases in ventricular filling pressure.. Pharmacokinetic Route - oral , iv Absorbed -60-80% Dose - 0.125-0.5% Protein binding -25% Elimination -35% Pharmacological actions .Heart - Direct effect on myocardial contractility . Blood vessels -Decrease peripheral resistance . kidney -causes diuresis . CNS - little effect on Interactions .Hypokelemia