Skip to main content

HYPERTENSION (HIGH BLOOD PRESSURE)

HYPERTENSION  Hypertension is a very common disorder  particularly in past middle age..  Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility..  Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of  your blood pushing , against the wall of the artries..  The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems ..  It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension   Dizziness   Highblood pressure   Nausea   Vomiting   Irregular heartbeat   Mental confusion *What causes Hypertension . High salt in you...
Post a Comment

Anti-anginal drugs (chest pain)

Angina (Ischemic angina) 
It is a chest pain caused by reduced blood flow to the heart ..
It is also called angina pectoris 
Angina pectoris 
It is a pain syndrome due to induction of an adverse oxygen supply/demand situation in a proportion of the myocardium..

Types of angina 
(1)-Classical angina(Stable angina)  -Attacks are predicatbly provoked by exercise, ,eating cotious ..when the increased energy demand is withdrwan.. 
(2)-Varient /Prinzmetal/Vasopastic angina
Attacks occur at rest during sleep and are unpredictables.. 
(3)-Unstable angina -Increase in duration and severity of attacks ,which may occur even during rest ..
Mostly due to rupture of an antheromatous plaque attacking platelets.

Classification of drugs -
.Terminate attacks -Nitrates 
.Used for chronic prophylaxis -other drugs 

 (1)-Nitrates 
 Nitrates dilate the veins more than artries, peripheral pooling of blood and decreased venus return (preload on heart reduced) end diastolic size and pressure reduced.
   Short acting nitrates -Glyceryl trinitrates 
   Long acting nitrates -Isosorbide 

(2)-Beta blockers
Reduced cardiac work and oxygen consumption as a consequences decrease in heart rate.. 
EX -propanalol, Metoprolol

(3)-Calcium channel blocker 
Interfere with calcium movement into the cell and slower the movement of calcium in the cell.. 
Ex-Verapamil, Diltiazem ,Amlodipine 

(4)-Potassium channel openers 
Regulate the movement of ion across the cell membrane ..
 Ex-Nicorandil

(5)Other antianginal drugs-Trimetazadine,        Ranolazine ,Dipyrmidole
Labels:

Comments

Anonymous said…
Great post!
September 2, 2020 at 2:06 AM
Post a Comment

Popular posts from this blog

Tetracycline

Tetracycline   It is a class of antibiotics having a nucleus of four rings..  They are bitter solids and are slightly water soluble..  Tetracycline classification   Short acting -Tetracycline oxytetracyclime  Intermediate acting -Democlocycline  Long Acting -Doxycycline, Minocycline  Mechanism of action   Tetracycline are specific inhibitors of bacterial protein Synthesis..  They bind to the 30s ribosomal subunit and thereby prevent the binding of aminoacyl plus RNA to the mRNA ribosome complex..  They also inhibit protein synthesis in the host, but areless likely to reach the concentration required because eucaryoticcls don't have tetracycline upateke mechanism..  Spectrum of Activity   Broad spectrum antibiotic active agianst gram positive and gram negative bacteria, spirochetes mycoplasma..  Pharmacokinetic   Orally absorbed The capsule shoud be taken 1 or 2 hour before food..  60-70% ab...
2 comments
Read more

Clinical trials

Clinical trials When the world is suffering from this pandemic and waiting for the vaccine, the researchers and scientist working hard to make covid-19 vaccine..  But all vaccine are in their phases of clinical trials.. After the successful completion of trials, vaccine is approved from higher authorities.. Before the clinincal trial, their is a preclinical trials In which the drug susbstance or sample,we made is tested on animals.. Only after the successful completion of preclinical trials..The drug sample is approved for clinical trials..  What is clinical trials?  The first proper clinical trial was conducted by the physician Linb.. Clinical trial is a systematic investigation in human subjects for evaluating the safety and efficacy of a new new drug substance..  There are 4 phases of clinical trials..     Phase 0   .Microdosing study    .Not been technally fully developed   . Nor mendatory    .Less than 1/...
4 comments
Read more

Chloroquine

Chloroquine is an anti malarial drug..  It is also known as chloroquine phosphate  Recently"Doctors found that Hydroxy chloroquine is  used in the treatment of coronavirus ,and it shows good result in the recover of  covid patients.. Hydroxy chloroquine reduce fever and fever is the main symptom of corona virus..  India supply chloroquine to many countries including Italy, America..  Chloroquine is an antimalarial drug that used to treat high fever caused by the mosquito bite ..  Hydroxy chloroquine is the metabolite of chloroquine , it is less toxic used to treat rheumatoid arthritis.. Mode of action  There is no well known action of chloroquine ' chloroquine used to inhibit the formation of hemozoin (HZ) from the released heam by the digestion of hemoglobin in there acidic vocule ..  The free heam then lysis membrane and leads to parasite death..  USES 1-Hepatic amoebiasis  2-Giardiasis  3-Clonorchis ...
1 comment
Read more