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HYPERTENSION (HIGH BLOOD PRESSURE)

HYPERTENSION  Hypertension is a very common disorder  particularly in past middle age..  Hypertension itself is not a disease, But a risk factor for cardiovascular mortality or mobility..  Hypertension is also known as (High Blood Pressure) .. Blood pressure is the force of  your blood pushing , against the wall of the artries..  The normal range of blood pressure is 120/80mmHg.. High Blood pressure or Hypertension is the condition, In which the blood vessels have persistently raised pressure .. Hypertension is a seriously mental health condition increased the risk of Stroke, brain, kidney and other problems ..  It is a major cause of premature death worldwide with upwards of 1 in 4 men and 1 in 5 women .. * What are the symptoms of hypertension   Dizziness   Highblood pressure   Nausea   Vomiting   Irregular heartbeat   Mental confusion *What causes Hypertension . High salt in you...
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Cardiac glycoside drug (Digoxin)

Digoxin
It is the source of digitalis lonata.. 
Digoxin is a cardiac glycoside drug 
And have cardiac inotropic property..
It contain aglycone part that are attached to one or more sugar(glucose or degitoxoce) .. 
The aglycone part contain cyclopentanoperhydrophenanthrene
Sterioid ring..

It is the only drug that are used to treat heart failure (Congestive heart failure) .. 

Mode of action 
Increases the contractality of the heart muscle, by inhibiting the activity of an enzyme (ATPase) 
And controls the movement of calcium, sodium, potassium into heart muscle.. 

Increases cardiac output with a subsquent decreases in ventricular filling pressure.. 

Pharmacokinetic  
Route - oral, iv
Absorbed -60-80%
Dose - 0.125-0.5%
Protein binding -25%
Elimination -35%

Pharmacological actions 
.Heart -Direct effect on myocardial         contractility 
.Blood vessels -Decrease peripheral     resistance 
.kidney -causes diuresis 
.CNS - little effect on 

Interactions 
.Hypokelemia 
.Thyrotoxicosis
.Ventricular tachycardia 
.Waffparkinson white syndrome 
.Severe hepatic disease 

Adverse effect 
.Abdominal pain 
.Anorexia 
.Diarrhea 
.Psycosis 
.Hyperapnoea

Uses 
.Heart failure 
.Arrythmia 
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